Anchoring 1 is the only skill needed. (Unless you actually want to man the Guns on your POS, in which case you will need the starbase gunner role in Corp, and Anchoring V)
Your corp will need a standing level 10 times that of the security of the space you want to put the pos up at!
So if you want to anchor your POS in a 0.7 Caldari System, your Corp will need a Faction standing with Caldari of 7.
If you have only one person in your corp with the required standings, you can get everyone else to leave corp for 24 hrs and anchor the POS after the next down time cycle when Corp standings are updated, once the POS is anchored you may invite everyone back into Corp!
You will be able to put up Labs, Hangars, Ship maintenance and standard defences in Hi-Sec, No Sov structures, jumping structures or refinaries are allowed in Hi-sec, and I'm not sure, but I believe some of the EW modules are also banned.
They anchor just like in low-sec/null sec, launch for corp, then anchor... Position as needed then finalise the anchor and once anchored activate.
Your POS will consume fuel as normal, but also will need Faction Charters (which you buy with LP or on the market) this is the only additional price for Hi-Sec.
POS' in Hi-sec are completely safe though.... Unless you get Wardec'd if your corp/alliance gets a war on my advice is in the 24 hrs before it starts, take down your POS until it stops, it's a pain logistically but it will almost certainly be a prime target for any battleship fleet.