I would like to add to GreatApe's answer. As of this writing, of all ships in highsec, the Orca is considered the least gankable relative to hauling capacity. Moreover, anything placed in its corporate hangar will not drop but is lost forever upon the ship's destruction, providing further disincentive to strike against it.

Alternatively, the stealth approach invokes use of either the blockade runner (e.g. Viator) or a covops (e.g. Helios), though, as has already been mentioned, without an insta-undock, neither stands a real chance. Here, the objective is obviously zero dps and this can be more effective than any tank. Note that no substitute exists for intelligent, prudent (paranoid) flying practices.

As above really all things are killable speaking from experience...

Not that long ago, my blocade runner got bumpped at 4-4 after my instawarp was active, was perfect timing and good on the pilot who attempted it, and only due to luck that it didn't lose it and it's cargo. I'm an experienced pilot, and if it wasn't for a fellow alliance member who happend to undock at the same time making him turn tail and run, it would have likely been toast as I doubt I could have lasted sufficiently to redock.

the re-enforced Jita node has helped alot since then, but apart from pilots being careless the number one reason ships get killed in Jita is Lag at the undock of 4-4... don't care how good your tank is without your active mods its toast quick.