One important thing, be on the look-out for the changes CCP will do in the patches.
For example, when PI was announced and the retirement of NPC sold POS Fuel was disclosed, I know a couple of people who invested by buying a LOT (for billions worth) of Guidance Systems (price was at 418 at the time) and now look at the price. They basically made 100 of billions for some of them (4billion invested turned into 100billions) as they have sooo many Guidance Systems stocked.
I did not look myself on the impact of Incursions but it seems a LOT of people are dying. Maybe there is something to invest in, like ships = what are the best ships used to run those incursions if there is any, ... I would do some research on the impact there.
I know it is not a direct answer but definitely a guideline to live by in a sandbox like Eve.